Anti Aging Medicine/ Medical Tourism

June 21, 2010

A-sante / Anti Aging Medical clinic and Spa

Filed under: Uncategorized — Tags: , , , , — admin @ 10:00 pm

By Tom Gegoire

Dear Friends,

I will share with you my hearts desire. That is to open A-Sante, both here in the states and Southern France.

Here is my Mission Statement.

A- Sante

Mission Statement

A life Changing Experience, Come stay with us a week and leave five years younger.

To transform hopelessness to a state of abundance, to a rich, and rewarding lifestyle.

To make a difference in a person’s physical, mental, emotional, and spiritual health.

The Spa Services I will include are:

Therapeutic Massage     Body wraps           Body Scrubs
Liposuction / body contouring techniques,
IPL photo rejuvenation
Tummy Tuck, face lift, fat removal shots
Hair removal , permanent natural make-up
Waxing  pedicure, manicure, facials,   age spot removal
Microderm abrasion , Botox injections to name a few.
For the Anti aging medical side we will have chelation, Hyberbaric Oxygen Chambers, and everyone one will arrive with their In depth blood test panels. Our Physicians will be from the best Medical Schools.
We will also be staffed with the best herbologist and homepaths from around the world.
There will be an on site Western Pharmcy that compounds, as well as an On site Chinese medical Herboligist.
The weeks stay will include all breakfast and a variety of classes for the week that will be life changing.
A sample of those classes will be how to purchase and prepare real food that has been proven to be both great cancer fighters as well as great allies in prolonging ones life. There will be classes on basic nutrition, stress relief, Yoga, Pilates,
and several forms of meditation including Qi Gong and Tai Chi.
Also on site will be a corporate Wellness Center and retreat with seating for several hundred and break out rooms to accommodate your corporate needs.
There will be live entertainment every night in our outside amphitheater as well as Golf, Tennis and Swimming.
On Friday evenings the medical staff will join our guest for for a casual complimentary barbecue and Talent night.
There will be locations in Northern California, Palm Springs, Northern Florida and the South of France.
More will be revealed. I need help with seed money of we have any altruistic investors out there.
Abientot,
Tom G

June 5, 2010

The Mightiest of Berries ( The Mighty Acai Berry )

By Tom Gregoire

Medical Jobs at UCSF posted at the bottom of this post. Thanks for coming by

Please feel free to visit the A-Sante Alternative medicine store  featuring

click here  (  http://astore.amazon.com/asan05-20   )

Acupuncture
Ayurveda
Flower Essences
Light Therapy
Magnetic Field Therapy
Manipulation Therapies
Oxygen Therapy
Single Homeopathic Remedies
Sound Therapy

Read Time : 4 minutes

Each day, every cell in the human body must withstand an estimated 10,000 individual assaults from externally introduced reactive oxygen species (ROS) or free radicals.1

The progressive, system-wide destruction wrought by this continuous biochemical onslaught has been thoroughly documented in the scientific literature. In the older cells of aging animals, to take one example, researchers have found that one out of every three proteins is rendered dysfunctional by unchecked free radical damage.2

In the search for optimal defense against free radicals, scientists have focused intensely on berry extracts. A growing body of scientific evidence shows that berry polyphenols’ antioxidant capacity powerfully targets numerous degenerative diseases, from cancer and atherosclerosis to impaired glucose control and blood lipid abnormalities.3-11

Touted commercially for years as a “superfood,” only recently has the açaí berry gained compelling scientific validation as an antioxidant powerhouse. Among the most recent findings:

  • After consuming a blend of açaí polyphenols, researchers recorded a three-fold increase in antioxidant capacity in the blood of healthy human volunteers.12
  • Antioxidants found specifically in freeze-dried açaí extract have been shown to enter human cells in a fully functional form and effectively neutralize free radicals at very low doses.13
  • Similarly, freeze-dried açaí extract has demonstrated unrivalled scavenging capacity against two of the most damaging reactive oxygen species, the superoxide and peroxyl radicals.14

In this article, you will learn how the antioxidant potency of açaí and other foods is assessed, using a measurement known as oxygen radical absorbance capacity, or ORAC.15,16 You will find out the most recent research indicating that the full polyphenolic profile of açaí affords optimal antioxidant protection. You will also gain insight into the specific health benefits of açaí and similarly potent fruits and vegetables—and their unrivalled power to combat free radical damage and the killer diseases of aging.

Assessing Antioxidant Potency

The standard index for determining the antioxidant value of various organic compounds is known as oxygen radical absorbance capacity, or ORAC.17-19 Developed by scientists at the USDA Human Nutrition Research Center on Aging at Tufts, the ORAC test is considered one of the most sensitive and reliable methods for measuring the ability of antioxidants to absorb free radicals. While other analytic methodologies may be used, ORAC is often considered preferable because of its biological relevance to antioxidant action in vivo (in living organisms).20 It measures both the degree and speed with which a certain food inhibits the action of an oxidizing agent, then integrates these two measurements into a single value, producing an accurate assessment of different types of antioxidants of different strengths.21,22

The ORAC value of a given food is proportional to its polyphenol content. Fruits and vegetables with a higher ORAC value—or richer color—have been shown to suppress free radicals more effectively than lightly pigmented foods.23 Scientists at the US Department of Agriculture advise that we ingest foods equivalent to 3,000-5,000 ORAC units per day in order to maintain optimal antioxidant protection in bodily tissues and plasma 24,25—a number that may be too low.

ORAC: Top-Ranked Antioxidant Foods
Açaí berries 18,400
Pomegranates 10,500
Blackberries 5,100
Bilberry 4,200
Blueberries 3,200
Plums 2,800
Raspberries 2,700
Strawberries 2,600
Oranges 2,400
Elderberry 2,200
Cherries 2,100
Black Currant 1,160
Red grapes 1,100
Broccoli flowers 900
Kiwi fruit 900
Beets 840
Red bell pepper 710
Grapefruit, pink 483
Onion 450
Corn 400
Eggplant 390
The numerical values above indicate ORAC units per 100 grams (about 3.5 ounces).26-29

Unrivalled Free Radical Defense

The açaí (Euterpe oleraceae Mart.) is a species of palm tree indigenous to the area surrounding the Amazon in South America. Its berries resemble grapes and ripen seasonally in similar fashion, progressing from green to a deep purple color.30 They have long served as a critical nutritional source for the native peoples of Central and South America. Modern scientific analysis revealed that the açaí berry’s complete polyphenolic profile boasts a formidable array of beneficial compounds, including polyunsaturated and monounsaturated fatty acids (11.1% and 60.2%, respectively), along with 19 health-promoting amino acids.31

Unrivalled Free Radical Defense
Click here to view

Celebrated in traditional cultures for its life-sustaining power, the magnitude of açaí’s antioxidant capability only recently emerged in scientific studies.32 Açaí powerfully counteracts several of the most destructive reactive oxygen species (ROS), or free radicals. In freeze-dried form, it has been shown to effectively inhibit the ROS superoxide in assays, and excels against the peroxyl radical in particular, with the highest reported total ORAC score of any fruit or vegetable.33 Açaí was also found to be active against the peroxynitrite and hydroxyl radicals in ORAC assays.34,35 It has also been identified recently as a potent COX-1 and COX-2 inhibitor, which may give it the ability to provide relief from pain and inflammation.36

A study designed to evaluate total free radical scavenging capacity among various antioxidant foods revealed that when compared to common European fruit and vegetable juices, all the açaí samples studied ranked in the top class of peroxyl radical scavengers.37 The authors found the samples to be so high in antioxidant capacity that the numbers could only be estimated. Another study found that human plasma antioxidant activity is significantly increased after the consumption of açaí pulp and juice, observing individual increases in plasma antioxidant activity of up to 2.3-3-fold, respectively.38

Its potent antioxidant properties and highly beneficial polyphenolic profile endow açaí with a singular ability to combat cellular aging and oxidative damage. The latest research reveals the potential for significant beneficial effects on longevity and incidence of chronic disease. A study on the life span and survival of Drosophila melanogaster flies found that dietary supplementation of 2% açaí increased the life span of females fed a high-fat diet by approximately 20%, compared to controls fed a high-fat diet without açaí.39 Açaí was noted to promote the activation of important stress-response pathways, alleviate the oxidative stress of aging, and protect against the negative effects of dietary fats.40,41

What You Need to Know: Scientific Validation for Açaí
  • Every cell in the human body withstands an estimated 10,000 individual strikes by free radicals each day, a leading factor in aging and degenerative disease onset.
  • Although promoted commercially for years as a nutritionally dense food, the deep purple açaí berry has only recently gained compelling scientific validation.
  • In a recent clinical study, a blend of complete açaí polyphenols increased antioxidant capacity three-fold in the blood of healthy human volunteers.
  • Antioxidants found specifically in freeze-dried açaí extract have been shown to enter human cells in a fully functional form and effectively neutralize free radicals at very low doses.
  • Freeze-dried açaí extract is also extraordinarily effective against the most damaging reactive oxygen species, the superoxide and peroxyl radicals.
  • Scientific research suggests that together with similarly pigmented foods rich in anthocyanins (blueberries, black currant, and raspberries), açaí may serve as a frontline defense against multiple diseases of aging.

Evidence is also building for açaí as a major cancer fighter. Polyphenolic mixtures of açaí pulp and oil extracts inhibited the proliferation of human colon cancer cells in the lab by up to 90.7%42 and a study on human leukemia cells found açaí polyphenols reduced cell proliferation from 56-86%.43 Açaí pulp was also found to be protective when administered to mice prior to the chemotherapeutic drug doxorubicin.44

Açaí is also emerging as a major cardiovascular protector.45 In one study, açaí extract induced long-lasting endothelium-dependent vasodilation (relaxing of the arterial wall) in the abdominal vascular tissue of rats.46 Supplementation with açaí berries has also been shown to reduce total and non-HDL cholesterol in animals with experimentally induced high cholesterol.47

Açaí’s high antioxidant capacity also benefits brain function, with potential implications for the treatment of neurological disorders, including Alzheimer’s disease and Parkinson’s disease. Research has shown that pre-treatment of brain tissue from the cerebral cortex, cerebellum, and hippocampus with açaí decreased ROS-induced damage of lipids and proteins in all brain tissues tested.48

Anthocyanins: Broad-Spectrum Disease Protection

Anthocyanins: Broad-Spectrum Disease Protection

The most powerful antioxidant berries to emerge in recent studies contain a class of polyphenols (plant-based compounds) known as anthocyanins. These nutrients produce the deep red, blue, and purple pigments found throughout the plant kingdom.

Fruits and vegetables bearing these colors—blueberries, cranberries, pomegranates, black currants, beets, and açaí—are especially rich in anthocyanins. Although present only in minute quantities, they are readily absorbed into the blood upon ingestion, where they initiate a physiological response in the body that quells free radical activity.

The most up-to-date research indicates that anthocyanins confer a broad array of health benefits, including:

  • inhibiting cancer cell growth and inducing apoptosis (programmed cell death) in several cancer cell lines49-52
  • reducing the risk of cardiovascular disease53-55
  • enhancing glucose tolerance and lipid profiles56,57
  • improving eye function58,59
  • limiting cellular oxidative DNA damage.60,61

An 8-week, randomized, placebo-controlled study published this year confirmed not only that they are highly bioavailable—they can also significantly increase levels of other beneficial polyphenols in the blood.62

In addition to açaí, anthocyanins are distributed widely among nature’s most brightly colored fruits and vegetables.

Other Beneficial Pigmented Plants

Blueberry

Blueberries have been shown to enhance cognitive performance, and are abundant in polyphenols that can cross the blood-brain barrier and localize in regions critical to learning and memory.63 Blueberries protect the myocardium from ischemic damage and prevent post-myocardial infarction heart failure.64 They have also been found to improve insulin resistance and thus glucose control in pre-clinical models.65 Taken together with probiotics, they may help counteract colitis (inflammation of the large intestine).66

Bilberry

This relative of the blueberry may provide a frontline defense against cardiovascular disease. Researchers have found that bilberry significantly inhibits angiotensin-converting enzyme, or ACE, which contributes to hypertension by promoting dangerous narrowing of the arteries (vasoconstriction).67 Bilberries enhance short-term memory in animal models, suggesting they may have potential to help ward off Alzheimer’s disease.68 Like many anthocyanin-rich foods, bilberries also inhibit proliferation of breast cancer cells and induce apoptosis in animal models.69 They improve insulin sensitivity, helping to prevent diabetes.70 Bilberry extract helps to upregulate enzymes that defend against ocular oxidative stress as well, suggesting it may be beneficial for protecting the eyes against age-related disorders, like macular degeneration.71

Black Currant

Black currant boasts potent anti-viral activity72 and has been shown to relax the aorta by enhancing the synthesis of nitric oxide.73 Black currant also reduced the oxidative stress induced by exercise and may enhance immune responsiveness to pathogens.74 One study found that black currant extract improved volunteers’ ability to adapt to the symptoms of tired eyes.75 Black currant has also been shown to stop the growth of certain harmful bacteria.76

Blueberries have been shown to enhance cognitive performance and are abundant in polyphenols… critical to learning and memory.

Cranberry

Cranberries are probably best known for the support they provide the urinary tract, by inhibiting the adherence of E. coli to the urethra and bladder.77 They’re also proven fighters of oxidative stress. An 8-week, double-blind, placebo-controlled trial involving 65 healthy women found that 1,200 mg of cranberry extract per day prompted a significant decrease in serum levels of advanced oxidation protein products—a key measure of oxidative stress.78 Cranberries also display anti-proliferative activity against several types of cancer in vitro and in vivo, including gastric cancer79 and esophageal adenocarcinoma.80 They may also help to fend off ulcers by preventing Helicobacter pylori, the bacterium which causes peptic ulcers, from adhering to the stomach lining.81,82

Blueberry, Bilberry, Black Currant , Cranberry, Elderberry, Pomegranate

Elderberry

Like black currant, elderberry is a natural anti-viral that shows promise in protecting against both seasonal and H1N1 swine influenza. Elderberry anthocyanins have been found to bind to H1N1 and block the ability of the virus to infect host cells. Researchers have favorably compared its activity to that of oseltamivir (Tamiflu®).83 A randomized, double-blind, placebo-controlled study on a standardized elderberry product found that it reduced the duration of the flu symptoms to just 3-4 days.84 The study also showed it to be effective against 10 different strains of influenza. Elderberry also reduces lipid peroxides, neutralizes lipid peroxyl radicals, inhibits LDL oxidation,85 and offers significant protection to endothelial cells against oxidative stress.86

Pomegranate

Pomegranate provides broad-spectrum benefits across many physiological systems. Extracts of pomegranate have shown promise in reducing the potential for metastasis in breast cancer.87 They initiate programmed cell death and inhibit the proliferation of prostate, lung, colon, and other cancers.88-91 The fruit has also been shown to reduce inflammation in colitis92 and suppress inflammation and joint damage in rheumatoid arthritis,93 not to mention its status as a known cardiovascular tonic.94

Other Beneficial Pigmented Plants

A rich variety of additional brightly pigmented foods afford similar health benefits.

Raspberries protect against DNA damage95 in HT-29 colon cancer cells, and inhibit HT-115 colon cancer invasion, in vitro.96 In combination with other berry extracts, raspberry extracts have shown efficacy against oral, breast, and prostate cancers in the lab.97 The antioxidant capacity of aronia or chokeberries have yielded some of the highest ORAC values recorded;98 drinking the juice of these berries reduces exercise-induced oxidative damage to red blood cells99 and in one study, a cholesterol-lowering effect was observed in animals with experimentally induced high cholesterol.100 Aronia has also been found to decrease lipid peroxidation and oxidative stress.101

Grapes and grape seeds have been shown to inhibit colon cancer cell invasion102 and decrease LDL oxidation and platelet aggregation, among other cardioprotective activities.103 Grapes have also been found to extend the life span of fruit flies, and may help combat Parkinson’s and other neurodegenerative diseases.104

Strawberry extracts have been shown to inhibit the growth of oral, colon, and prostate cancer cells,105 improve lipid profiles and peroxidation106 and lower the risk of coronary artery disease.107

Other Beneficial Pigmented Plants
Click here to view

Blackberries have shown themselves to be extremely beneficial in the management of inflammation, suppressing pro-inflammatory cytokines in animal models. Blackberry extracts also show potential in inhibiting the growth of human colon cancer cells in the laboratory, suggesting a potential role in cancer prevention.108

Cherries have been found to reduce blood lipid abnormalities109 and glucose intolerance and abdominal obesity in mice.110,111 Tart cherries have been found effective in suppressing inflammation-induced pain.112

The benefits of anthocyanins are not limited to fruits: studies have shown that the black soybean shows promise in fighting colon cancer113 and insulin resistance,114 and promotes wound healing in skin cells and reduces inflammation in endothelial cells.115

Purple corn possesses anti-mutagenic effects, reducing expression of genes involved in proliferation of tumor cells.116,117

Summary

Each day, every cell in the human body withstands 10,000 individual strikes by free radicals, a leading factor in aging and degenerative disease onset. In the search for optimal defense against free radicals, scientists have focused intensely on berry extracts for their potent antioxidant capacity. Although promoted commercially for years as a nutritionally dense food, the deep purple açaí berry has only recently gained compelling scientific validation. In a recent clinical study, a blend of complete açaí polyphenols increased antioxidant capacity three-fold in the blood of healthy human volunteers. Antioxidants found specifically in freeze-dried açaí extract have been shown to enter human cells in a fully functional form and effectively neutralize free radicals at very low doses. Freeze-dried açaí extract is also extraordinarily effective against the most damaging reactive oxygen species, the superoxide and peroxyl radicals. Scientific research suggests that together with similarly pigmented foods rich in anthocyanins (blueberries, black currant, and raspberries), açaí may serve as a frontline defense against multiple diseases of aging.

Here are the Medical jobs at UCSF as of 6/9/10

Campus
SCIENTIST, CLINICAL LAB
32924BR SFGH Clinical Laboratory
The University of California Regents has implemented pay reductions and furloughs due to the State of
California budget crisis. This position may be subject to the pay reductions through August 31, 2010.
Performs all routine and special hematology, coagulation, urinalysis and blood gas testing; responsible for
the proper operation of instruments, including maintenance, troubleshooting and quality control; must be
able to work independently, recognize problems, identify cause and determine solutions; must be able to
work under pressure and maintain a high level of organization, accuracy and efficiency; incumbent will also
perform other duties as assigned. Note: $5,000 sign-on bonus.
Graduation from college with a major in an appropriate scientific field, possession of a clinical laboratory
scientist license or a similar license of equal or higher level issued by the State Department of Health; and
knowledge and abilities essential to the successful performance of duties assigned to the position; able to
work independently, under pressure; recognize and resolve problems while maintaining a high level of
organization; excellent verbal and written English communication skills. Note: Start date is contingent upon
proof of TB testing within the past year. Fingerprinting and background check required.
Requirements
Job Summary
Administrative Support
_____ASSISTANT III
32995BR Surgery
The University of California Regents are implementing pay reductions, furloughs and/or other types of
measures due to the state budget crisis. This position would be subject to any cost cutting measures
implemented at UCSF. Given the significant increase in funding and projects in the Breast Care Center
(BCC) and the BCC Research Program, an administrative analyst is required to support the financial and
administrative work in the BCC; the incumbent will primarily serve to provide analytical and administrative
management support to the Research Programs Director and overflow support for the BCC Executive
Director; the position will contribute substantively to the development and implementation of the overall
administrative organization, procedures, and special projects – especially related to the new I-SPY Program;
the incumbent will provide analytical and administrative support for a variety of activities throughout the
BCC, and perform other duties as assigned.
High school graduation and four years of related administrative experience; or an equivalent combination of
education and experience; knowledge of or experience with basic techniques or methods required by the
position; excellent interpersonal, verbal and written communication skills and the ability to interface with all
levels of staff and leadership; ability to work in fast paced, team based, dynamic environment; ability to
meet deadlines, multi-task, and work under pressure; high degree of commitment, flexibility, selfmotivation,
self-confidence, assertiveness, and high tolerance of ambiguity; excellent problem solving
ability; self-starter with the ability to work both independently and with teams; ability to interpret and apply
policies and regulations; demonstrated ability to be self directed with excellent organizational, analytical,
and detail; Orientation inter-personal and project related skills; demonstrated reliability and attendance;
knowledge of breast cancer terminology in order to assist with grant review documentation and submission;
experience working in an academic and research unit in order to provide academic support to researchers
and Administrative Directors; experience coordinating meetings and events with academic or research
institutions; experience with Microsoft Office Suite (Word, Excel, Outlook, PowerPoint), survey/meeting
planning tools (e.g., Survey Monkey), and research publication tools (PubMed and Endnote).
Requirements
Job Summary
33024BR S/D PRDS
Job Summary
Tuesday, June 08, 2010 UCSF Employment Opportunities Bulletin Page 3 of 13

Medical Center
Administrative Support
_____ASSISTANT II
33030BR Pediatric BMT
Under the general direction of the BMT Clinical Office Analyst, incumbent will provide comprehensive
administrative support to the Pediatric Bone Marrow Transplant service: schedule clinic appointments for
new and follow-up patients using IDX, schedule/arrange all post-transplant patient evaluations, compile all
necessary lab work and evaluations for clinic using STOR and schedule interpreters as needed; handle
phones including triaging of many messages; interact with patients, families, referring physicians, and billing
office; work with financial counselor to obtain insurance authorizations; maintain patient records and charts;
perform data entry in Peds BMT specialized database; transcribe and edit medical documents including
weekly conference agendas, letters and memos; and perform other duties as assigned.
· High School graduate or equivalent with three years related experience; · Ability to use good
judgment and work independently, at times under the pressure of deadlines · Ability to asses situations,
prioritize workload, develop solutions and make recommendations. · Excellent customer service and
communication/interpersonal skills, both over the telephone and directly. · Basic math skills
required. · Strong computer skills, including basic keyboarding skills, and experience with at least
two Office-type software programs (i.e., Word or Excel). · Proven ability to deal with a wide variety
of individuals; · Ability to deal sensitively and effectively with patients. · Excellent
organizational and problem-solving skills. · Demonstrated administrative/office coordination skills;
Requirements
Job Summary
Nursing – Advanced Practice|Nursing – Perioperativ
NURSE, ANESTHETIST, SR
33015BR SOM Anesthesia
The Certified Registered Nurse Anesthetist is responsible to administer anesthesia to patients undergoing
surgical and obstetrical procedures at the Mount Zion and/or Parnassus site operating rooms, or to patients
undergoing diagnostic or therapeutic procedures outside the OR, under the supervision of a faculty member
of the Department of Anesthesia & Perioperative Care at the UCSF Medical Center. Duties Include: 1.
Determines the condition of patients prior to a procedure by reviewing medical records, assessing patient’s
status, conducting a thorough preoperative evaluation, and physical exam of the patient. 2. Plans for and
administers anesthetics, including inhalation, intravenous, and regional techniques. 3. Observes, monitors,
and records vital signs and other parameters. 4. Inserts invasive monitoring lines for an anesthetic, and for
interpretation of physiologic data. 5. Maintains patients in a surgical anesthetic state. 6. Determines the need
for, and administers fluids, blood products, and adjunct drugs. 7. Keeps the surgeon and responsible
anesthesiologist informed of the patient’s condition. 8. Takes necessary remedial action to correct
unacceptable changes in vital signs. 9. Documents anesthetic in accordance with legal requirements; records
type of anesthetic used. 10. Performs post-operative follow-up in the recovery room. 11. Communicates with
the assigned anesthesia faculty member, as needed, before, during, and after surgery. 12. When not assigned
to a case, is available for work as needed, determined by the responsible anesthesia faculty physician. 13.
Provides anesthesia care to patients at all the UCSF locations where anesthesia services are currently used,
and where anesthesia services will be required in the future. Prior to the date of hire, the incumbent will be
required to complete a credentialing process which may take up to 60 days.
• Graduation from an accredited school of nursing and possession of the legal requirements to practice as a
Registered Nurse as determined by the California Board of Registered Nursing • Graduation from a school
of anesthesia accredited by the Council of Accreditation of Schools of Anesthesia • Certification by the
Council for Certification of Nurse Anesthetists • Knowledge and activities essential to the successful
Requirements
Job Summary
Tuesday, June 08, 2010 UCSF Employment Opportunities Bulletin Page 12 of 13

Allied Health
____ASSISTANT, HOSPITAL I
33002BR SFGH Clinical Laboratory – Specimen Collection and
The University of California Regents will implement pay reductions, furloughs and/or other types of
measures due to the state budget crisis. This position will be subject to any cost cutting measures
implemented at UCSF. The incumbent will answer multi line phone system and transfer calls as required;
accurately and clearly communicate information obtained from the laboratory manual and the laboratory
computer system to hospital staff, patients and telephone healthcare providers to report specimen problems
and critical patient results; provide specimen containers and gives collection instructions as necessary;
receive, timestamp, and document specimens into the laboratory for testing; prioritize blood, urine, stool,
and body fluid specimens for routine or priority handling; determine suitability of specimens; centrifuge
specific blood and non-blood; specimens; use pneumatic tube for sending and receiving specimens; and
perform other duties as assigned. For questions, please send email to sallie.holloway@ucsf.edu.
High school graduation or GED, and one year of related experience, or equivalent combination of
education/experience; knowledge of medical/clinical laboratory terminology; ability to communicate clearly
in the English language both verbally and written; strong interpersonal skills and demonstrate willingness to
be a team player; knowledge of computers; start date is contingent upon proof of TB testing within the past
year. Note: Fingerprinting and background check required.
Requirements
Job Summary
Tuesday, June 08, 2010 UCSF Employment Opportunities B

Other Nursing
NURSE, CLINICAL II
33000BR Helen Diller Family Comprehensive Cancer Center
The University of California Regents are considering implementing pay reductions, furloughs and/or other
types of measures due to the state budget crisis. This position would be subject to any cost cutting measures
implemented at UCSF. The UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC) is an
interdisciplinary Center with the goal to shepherd new approaches to cancer prevention, detection, and
treatment into clinical and population settings. A Research Program Nurse is needed to provide clinical
resources for a team of 8-10 Analyst I-II, Clinical Research Coordinators; liaise with inpatient hospital units
(including the ICU); establish procedures for studies conducted in the inpatient environment; translate
protocols to medical orders, conduct in-service education meetings ensuring that training competencies have
been accomplished; coordinate training with the HDFCCC CRC training program, led by the Nurse
Educator; work closely with Lead CRC to monitor; collaborate with the HDFCCC clinical research unit in
the day-to-day training, assure that CRC’s utilize the system consistently, manage time appropriately and
collect data according to GCP’s. The incumbent will assist with projects, patient coverage, and other RN
duties as needed and whenever necessary. One of the goals for this position is the accomplishment of data
management issues by facilitating effective, timely reporting either at weekly scheduled protocol review
meetings or one-on-one meetings with CRC staff; and will perform other duties as assigned.
Possession of the legal requirements to practice as a Registered Nurse as determined by the California Board
of Registered Nursing and six months of clinical experience; previous experience in the recruitment of
potential clinical study participants in a busy multi-practice university setting; a minimum of two years of
experience in research or oncology nursing; a minimum of two years Clinical Research experience with
experience in recruitment of subjects; demonstrated knowledge of the ICH guidelines for Good Clinical
Practice; Institutional Review process; Federal Code of Regulation that pertain to human clinical research
and JACHO policies for in-patient and out-patient hospital areas; team player.
Requirements
Job Summary
Professional and Managerial
ANALYST I
32999BR Medicine – Hematology/Oncology
The University of California Regents has implemented pay reductions and furloughs due to the State of
California budget crisis. This position may be subject to the pay reductions through August 31, 2010. The
GI Oncology Program is a dynamic and growing multidisciplinary team focused on cancer research;
program members are involved in conducting translational research including studies authored by Program
Investigators and collaborative research projects with multiple cancer centers, private companies in biotech,
philanthropies and pharmaceutical industries. Under the general direction of the Program Leaders, the
Program Analyst will provide regulatory administration, data and project management, development and
administrative support for the National Comprehensive Cancer Network (NCCN) Neuroendocrine Outcomes
Database; the incumbent’s responsibilities will include: responsible for the collection, management, and
review of patient clinical data and interfacing with Program Investigators, and study sponsors; clinical data
and database project management activities will include careful and timely maintenance of accurate database
files; interpreting; abstracting data from various medical record sources and report generation; and
performing other duties as assigned.
BA/BS with a major in Biology or health care or a related field and one year of experience in administrative
analysis or operations research; or an equivalent combination of education and experience; demonstrated
proficiency in medical terminology, human anatomy and physiology; proficiency with MS Word, Excel, and
other Microsoft Office applications; ability to think independently and work within a team-based and
dynamic environment; excellent organizational skills; excellent verbal/written communication and analytical
skills; ability to relate effectively in person and on the telephone with physicians, nurses, data managers, as
well as medical records and information science departments required; requires bending, climbing stairs;

ANALYST III
33021BR Human Research Protection Program
NOTE:The University of California Regents are considering implementing pay reductions, furloughs and/or
other types of measures due to the state budget crisis. This position would be subject to any cost cutting
measures implemented at UCSF. Under the supervision of the Associate Director, the Cancer Center
Assistant Coordinator will work within the HRPP and in close liaison with UCSF’s Helen Diller Family
Comprehensive Cancer Center and especially the Cancer Center’s Investigational Therapeutics Initiative
(ITI) to facilitate the review and approval of human research applications submitted by Cancer Center
faculty. As guided by broad priorities established by HRPP and the Cancer Center, incumbent will analyze
and evaluate proposed projects and programs involving human research subjects as well as specific
applications to the Committee on Human Research; determine which projects and applications need
incumbent’s attention; and provide advice to faculty and staff on how the projects, programs, and
applications can best comply with ethical, regulatory, and procedural requirements for human research
approval. As needed, incumbent may provide training to individuals or groups of staff in the preparation of
applications; attend Cancer Center meetings as needed to remain familiar with Cancer Center concerns and
provide advice related to human subjects protections; screen and edit applications for CHR approval and
return them to researchers for changes; prepare template forms that can serve as models for numerous
applications; attend CHR meetings where high priority studies are reviewed; consult with CHR chairs and
vice chairs regarding concerns and priorities; draft correspondence conveying CHR concerns to
investigators; screen researchers’ responses to CHR correspondence; advise researchers on steps needed to
obtain final approval; and ensure rapid handling by HRPP of high priority Cancer Center applications.
Incumbent will maintain and apply broad knowledge of Cancer Center research activities and priorities and
IRB standards, policies, and procedures. Incumbent will also coordinate UCSF correspondence and IRB
Facilitated Reviews with the National Cancer Institute’s Central IRBs to ensure UCSF Cancer Center faculty
can fully participate in national cooperative group studies; and will perform other duties as assigned.
BA/BS with a major in life, physical, social sciences or related field and three years of experience in
administrative analysis or operations research; or an equivalent combination of education and experience;
minimum 3 years work experience in the human subject protection program or in clinical research; sufficient
professional experience, adequate education, and sound judgment to comprehend, interpret and analyze
publications and reports concerning applicable policies, procedures, and regulations and California laws; a
proven working knowledge of a significant body of scientific and medical concepts and terminology; ability
to work both independently and cooperatively in a high-pressure environment; demonstrated ability to retain
confidentiality, exercise judgment and make sound decisions; demonstrated ability to communicate clearly
and effectively both verbally and in writing; ability to write general committee correspondence and summary
analysis; ability to investigate and analyze scientific topics on the internet and in biomedical journals; strong
organization skills; must multi-task, be organized, able to re-prioritize tasks as needed, and be flexible;
ability to work well with a wide variety of customers, including faculty members, committee members and
chair persons, committee staff, senior academic administrators, federal regulatory officials and funding
agency auditors in a thoroughly and consistently professional manner; flexibility and willingness to provide
backup as needed, for assigned projects; proficiency with MS operations, including advanced skills in Word
and Excel. Note: This is a critical position; fingerprinting and a background check required.
Requirements
Job Summary
33029BR Research
NOTE:The University of California Regents are considering implementing pay reductions, furloughs and/or
other types of measures due to the state budget crisis. This position would be subject to any cost cutting
measures implemented at UCSF. The Contracts and Grants Division is the office of record for all contracts
and grants for research, training, and public service proposed and received by UCSF; it is responsible for
contract and grant analysis and implementation, review and submission of all contract and grant proposals,
negotiation of award terms and conditions, and certain post-award activities including close-out; Contracts
and Grants is directly responsible for the accurate review and processing of all extramural funds received at
UCSF including federal and private non-profit grants, federal, state, and municipal contracts and fellowship
awards; additionally, the Division works with UCSF faculty and staff as well as funding agency officials to ensure compliance with University and external regulations. This Pre-Award Analyst reviews federal and
non-profit grant and fellowship proposals as well as federal, state and city contracts for compliance with
University and awarding agency requirements, proper facilities and administrative cost application, budget
analysis, CAS/A21 review, and inclusions of compliance certifications as needed, etc.; serves as point of
contact with campus research administrators and advises departmental staff/faculty on proposal preparation
and proper interpretation of federal and non-profit award terms; post-award administration activities include
review/processing of re-budgeting actions, review of federal agency terms and conditions for University
acceptance, and reviewing/correcting proposal information entered into electronic Research Administration
system for federal proposals and awards; the Pre-Award Analyst is expected to develop the requisite
knowledge and expertise to be granted signature authority for sponsored agreements and perform other
duties as assigned.
BA/BS with a major in a related field and three years of experience in administrative analysis or operations
research, or an equivalent combination of education and experience; ability to obtain assigned levels of
signature authority on behalf of the University; able to comprehend and interpret complex language related
to federal, non-profit and University regulations in order to ensure that research practices are in accordance
with regulatory requirements and ethical standards; knowledge of grant submission process including
preparing, completing, and collecting required information for federal and non-federal grant applications;
ability to work independently and cooperatively in a high-pressure environment, with time sensitive
deadlines; ability to manage several projects simultaneously; ability to work independently and
cooperatively in a high-pressure environment, with time sensitive deadlines; ability to manage several
projects simultaneously; excellent verbal and written communication skills are essential to interact
effectively with diverse internal and external professional groups and sponsors; word processing experience
and the ability to learn database systems and use electronic portals for proposal submissions; previous
administrative experience working with grants/contracts required or similar complex administrative
experience. Background Check and Fingerprinting Required for this critical position.

FUNDRAISER II
32972BR University Development and Alumni Relations
NOTE:The University of California Regents are considering implementing pay reductions, furloughs and/or
other types of measures due to the state budget crisis. This position would be subject to any cost cutting
measures implemented at UCSF. The UCSF Foundation and the Office of University Development and
Alumni Relations (UDAR) are responsible for fostering and strengthening the campus outreach efforts to
UCSF constituents and for garnering private support for the campus. In raising private support, UDAR
identifies, qualifies, solicits and stewards donors for the schools, medical centers, departments and programs
on campus; for formal acceptance and administration of all private gifts to the university through The
Regents or the UCSF Foundation; and for managing all alumni relations activities, campus support group
activities and campus events. The office is also responsible for the design and implementation of
fundraising campaigns for UCSF. The Director, Annual and Special Giving is a key member of UCSF’s
Children’s Hospital and Health program; will help managing the strategic planning process for the central
Annual Giving campaigns for the Department of Pediatrics and Children’s Hospital. Clients/stakeholders
therefore include the Chancellor, dean of the School of Medicine, and the Medical Center CEO. The
incumbent will work with the CEO of the Medical Center, Dean of the School of Medicine, Chair of
Pediatrics, the Executive Director of Development, Children’s Hospital, the Senior Director, Annual and
Special Giving, and the Director of Development Marketing to create annual strategic and operating plans
for integrated direct mail and telemarketing campaigns; set annual fundraising goals, identify key casebuilding
messages, and develop segmentation strategies and work closely with all clients/stakeholders,
Senior Director, Annual and Special Giving, and the Director of Development Marketing, manage the
creative development process; will also work to identify, cultivate, solicit, and steward prospects in the
range of $100,000.
Bachelor’s degree and experience in non-profit institutional development or an equivalent combination of
education and experience; considerable experience in Annual Giving and/or direct response marketing is
required; superb writing skills and excellent creative judgment; well-developed interpersonal skills,
including a strong service orientation and the ability to supervise staff; ability to work independently with
minimal supervision in a complex and challenging environment. Note: Fingerprinting and background
check required for this critical position.
Requirements
PROGRAM REPRESENTATIVE III
32997BR Microbiology and Immunology
NOTE:The University of California Regents are considering implementing pay reductions, furloughs and/or
other types of measures due to the state budget crisis. This position would be subject to any cost cutting
measures implemented at UCSF. The Department of Microbiology & Immunology is a basic science
department within the School of Medicine. We perform scientific research and training. The Department is
home to two Graduate Programs, the Immunology Program and the Microbial Pathogenesis Program, and
has a central mission to teach Microbiology and Immunology to professional students in the Schools of
Medicine, Pharmacy and Dentistry and to graduate students pursuing their Ph.D. degree. This position is
being created to independently coordinate all of the Department’s Teaching and Graduate Program
activities. The job duties will include producing course syllabi, maintaining program websites, overseeing
classroom assignments, coordinating two seminar series, coordinating two journal clubs, coordinating two
program retreats per year, preparing course materials and coordinating all classroom data collection (i.e.
absences, evaluations, exams). A major responsibility for this position will be to revamp the current
administrative processes for the Immunology and Microbial Pathogenesis programs. The current
administrative structure is not working and this position will be responsible for evaluating the current
systems, as well as designing and implementing new systems and procedure; perform other duties as
assigned. The success of the administration of these programs will rest with this position.
Graduation from college and three years of related experience; or an equivalent combination of education
and experience; demonstrated course organization and administration experience; excellent analytical,
interpersonal, organizational and problem-solving skills; ability to complete all tasks with detail and
precision; demonstrated organizational, analytical and coordinating skills; ability to longitudinal plans for
parallel completion of multiple tasks; ability to anticipate needs and problems; proven ability to work
effectively with a wide variety of individuals and perform as part of a team; excellent demonstrated record
of attendance and reliability; excellent computer skills including use of Internet and e-mail, Microsoft Excel,
Word, PowerPoint, PhotoShop and Illustrator; strong writing skills that include the ability to compose, edit,
and proof a wide variety of documents, including confidential documents such as faculty evaluations and
student grades, with attention to detail; ability to use good judgment and discretion, and work independently
under the pressure of deadlines; ability to adapt with the evolving needs and responsibilities of faculty
supervisors and the courses and programs they direct.
Requirements
Job Summary
Professional and Managerial|Research and Scientifi
ANALYST IV
33003BR Family and Community Medicine
The University of California Regents are implementing pay reductions, furloughs and/or other types of
measures due to the state budget crisis. This position would be subject to any cost cutting measures
implemented at UCSF. The mission of the Department of Family and Community Medicine (DFCM) is to
educate students and residents in family practice with an emphasis on meeting the needs of the economically
disadvantaged and the medically underserved; to advance knowledge in family and community medicine;
and to develop methods of primary care that are effective, efficient, and accessible to all people; the
Department of Family and Community Medicine is internationally recognized for our pioneering research
programs in primary care and community health. The Center on Social Disparities in Health (the Center),
which is housed in the Department of Family and Community Medicine, has funding from the William K.
Kellogg Foundation (WKKF) for a nine-month planning phase of a proposed major project designed to
improve African-American birth outcomes and infant survival in California by directly and intensively
targeting social determinants of infant and maternal health; the funds requested will support the development
of the specific intervention protocols, project implementation strategies, and overall evaluation plans for that
larger project, which is currently under review at WKKF. The purpose of this position will be to act as
Project Coordinator of the planning phase, and ultimately of the larger project should it be funded; the
Project Coordinator will play a lead role during the initial 9-month planning period in developing protocol
and training materials for the two interventions featured in the full project: a group-based curriculum that
focuses on promoting financial management capacity among California Black Infant Health (BIH) program
Job Summary
Tuesday, JuneJob Summary
Tuesday, June 08, 2010 UCSF Employment
Job Summary
Tuesday, June

March 14, 2010

The Only Real Gaurantee to Living Longer

Filed under: Uncategorized — Tags: , , , — admin @ 10:04 pm

By Tom Gregoire

Read Time: 7 Minutes

Five Natural Compounds Simulate Caloric Restriction

The most scientifically validated way to extend life span—from single-celled organisms to mammals—is caloric restriction.1 This technique has been shown to boost life span by nearly 100% in some species.2

Reducing the number of ingested calories—while maintaining healthy intake of essential nutrients—triggers a cascade of anti-aging mechanisms in the body. More than 70 years of research have established its life-extending power.3

Modern science has only recently begun to unravel the mystery behind how calorie restriction so radically extends life span. At its core lies favorable alterations in gene expression—one of the body’s adaptive responses to reduced calorie intake. By activating certain genes and disabling others, caloric restriction dramatically slows aging.

This retardation of aging delays the onset of degenerative disease while improving biomarkers of youth, ranging from metabolic rate and insulin sensitivity to cardiac health and cognitive function.4

By the same token, the consequences of caloric overconsumption are equally profound. Every excess calorie brings you one step closer to age-related illness and death.

This is true at any stage of life, whether you’re lean or overweight, regardless of your health or nutritional status.5-7

Eating more than your body needs (excessive energy intake) can load the blood with triglycerides, glucose, homocysteine, and pro-inflammatory chemicals. The results are accelerated aging processes, prompting deterioration across multiple biomarkers of health.8

Most humans find it difficult to submit to a sufficiently rigorous dietary regimen, leaving the benefits of calorie restriction tantalizingly out of reach. Until now!

In this article you will discover the most compelling evidence to date on the effects of caloric restriction. In a milestone 20-year study of Rhesus monkeys—our close genetic relatives—a modestly restricted diet resulted in a three-fold reduction in the risk of age-related disease!9

You will also learn about five natural compounds that favorably modulate gene expression to support a more youthful health profile. These “caloric restriction mimics” simulate many of the beneficial effects of caloric restriction through multiple pathways.

Aging individuals may now enjoy some of the youth-promoting, disease-fighting mechanisms of caloric restriction—without strict dietary measures.

A Milestone in Longevity Research

In 1989, a group of anti-aging researchers launched what would prove to be the most comprehensive study of caloric restriction (CR) to date.10 Rhesus monkeys were chosen as subjects because they exhibit biological and aging characteristics strikingly similar to humans. The results, published in 2009 in the prestigious journal Science,9 provide compelling evidence of CR’s age-delaying, disease-fighting power.

The monkeys were split into two groups. Half were allowed to eat naturally, without restraint; the other half subsisted on a nutrient-replete diet 30% lower in total calories than they would normally consume. After 20 years, 37% of controls had died of age-related causes, as opposed to just 13% in the calorie-restricted group. In other words, caloric restriction cut degenerative disease risk by a factor of three.9

This study’s findings are even more tantalizing when one sees that it did not require severe lowering of calorie intake to produce these striking results. Americans typically consume 100% more calories than they need. It only required a calorie reduction of 30% to achieve the remarkable benefits in this study.

The Rhesus monkey study also conclusively demonstrated caloric restriction’s protective power. Over the course of 20 years, virtually all measured biomarkers of health were superior in the CR group.9

These findings have profound implications for humans. Rhesus monkeys are as vulnerable to chronic, age-related disease as we are. They lose their strength over time. Many become obese, fall prey to metabolic syndrome, and succumb to diabetes. They develop cardiovascular disease and cancer. And like aging humans, their brains shrink as they get older.


Yet among the calorie-restricted group, incidence of cardiovascular disease was half the rate of­controls. Not one member exhibited any symptoms of impaired glucose control or diabetes, whereas 40% of monkeys who ate as much as they wanted had become diabetic or pre-diabetic.9

Calorie-restricted monkeys lost fat weight, but did not sustain loss of muscle mass observed in the control group. CR also inhibited reduction in brain volume, especially in areas governing cognitive and motor function.9

The robust health of the CR group compared to controls is clearly evident in photographs of the monkeys from the control and CR groups.9 (See figure 1 below.)

Benefits of Calorie Restriction in Humans

All available data indicate that calorie restriction also slows aging and reduces the risk of killer diseases in humans as well. Individuals who impose a 20% reduction in their calorie consumption for 2-6 years lose fat weight and show significant improvement in their markers of aging, including blood pressure, cholesterol levels, and glucose control.11

Even brief periods of caloric restriction can temporarily improve core body temperature and insulin sensitivity, which happen to be markers of longevity.11,12 In clinical studies, short intervals of caloric restriction have reduced systemic inflammation—an underlying factor of so many chronic, degenerative diseases.

More youthful heart muscle performance13 has also been observed—caloric restriction appears to increase the number of vital energy-producing mitochondria in heart and skeletal muscle, reducing the oxidative damage that accelerates aging.14-16

No other intervention documented in the scientific literature can compete with caloric restriction as a candidate for slowing aging and supporting youthful health in humans.


It is regrettable that most aging individuals don’t lower calorie intake by the 20-30% reduction required to reap the benefits of caloric restriction, as it can dramatically lower disease risk and add years to their lives.

Caloric Restriction “Mimics” and Gene Expression

The problem many people have in sufficiently reducing their calorie intake has led to a novel scientific solution.

Researchers have identified a select group of nutrients that trigger many of the same underlying mechanisms of action as caloric restriction. Among the most promising of these caloric restriction mimics and enhancers are resveratrol, pterostilbene, quercetin, and grape seed extract, along with black tea extract. These nutraceuticals have been shown to generate many of the same effects in the body as caloric restriction, without significant dietary modification. In particular, they “mimic” caloric restriction’s favorable impact on genes that influence the aging process.


Life Extension - Health And Medical Findings

Genes have the capacity to directly affect life span by regulating a broad spectrum of aging factors, from inflammation and metabolic function to immune response. Calorie restriction exerts a beneficial effect on the activity of gene expression, supporting healthy cellular function through numerous physiological pathways. This includes:

  • Blocking inflammatory factors
  • Optimizing fat and carbohydrate metabolism
  • Lowering serum glucose
  • Supporting endothelial function
  • Inhibiting cancer development and proliferation

Compounds that mimic caloric restriction bring about favorable changes in gene expression and improve the primary biomarkers of aging.

What You Need to Know: Caloric Restriction

Excessive caloric intake is strongly associated with the onset of degenerative disease and shorter life span.

Research shows that calorie restriction (CR) can extend life span and afford significant protection against age-related disease in many animal species.

A landmark 20-year study demonstrated that caloric restriction powerfully counters the effects of aging in primates closely related to humans. CR produced a three-fold reduction in mortality from age-related conditions.

A caloric restriction regimen strict enough to yield these benefits is difficult or impractical for most people.

Nutrients known as “caloric restriction mimics” (or mimetics) afford a novel scientific solution. Working in tandem, their biomolecular action exerts similar effects on gene expression, providing the benefits of CR without severe dietary modification.

Resveratrol, pterostilbene, quercetin, and extracts of grape seed rank among the most promising of CR mimics, while the polyphenols in black tea support these metabolic effects. Research shows that they powerfully inhibit systemic inflammation, enhance mitochondrial health, prevent cancer, and protect brain and heart tissue from age-related deterioration.

Controlling Nuclear Factor-Kappa B

Calorie restriction sharply limits expression of nuclear factor-kappa B (NF-kB). In the cells, NF-kB is a critical gene regulator that governs response to pro-inflammatory cytokines, free radicals, cholesterol levels, immune function, and cancer prevention.17-24

The nutrients that mimic caloric restriction also act to stabilize NF-kB regulation and help combat the age-related conditions associated with unfavorable NF-kB activity.

Resveratrol activates sirtuins,25 a powerful family of “information regulator” proteins that inhibit NF-kB, reducing inflammation throughout the body, such as that caused by second-hand cigarette smoke.24 Resveratrol also prevents inflammatory mast cells from releasing the histamines that trigger asthma and allergic reactions.26

Resveratrol radically decreases production of the adhesion molecules that attract inflammatory cells to vascular walls, one of the principal mechanisms of atherosclerosis.27,28 Adhesion molecules also permit cancer cells to invade tissue and metastasize. Resveratrol’s influence over NF-kB has also enhanced beneficial UV-induced programmed cell death (apoptosis) in skin cancer cells.29


Life Extension - Health And Medical Findings

Found in blueberries, pterostilbene is a polyphenol closely related to resveratrol.30 It limits NF-kB activity through multiple complementary mechanisms.31 In vitro, pterostilbene suppresses invasive tumor activity and enhances therapeutic destruction of cancer cells.32,33

Quercetin’s ability to protect against chronic inflammatory conditions such as asthma, inflammatory bowel disease, and arthritis is due in part to its capacity for NF-kB inhibition.34,35

Grape seed extract also disrupts cellular inflammation signaling by blocking NF-kB.36 Its effect on pro-inflammatory cytokine production in fat cells may even help combat obesity and type 2 diabetes.37

Black tea extract’s influence on NF-kB activity has been shown to specifically protect cells from damage associated with inflammation,38 cancer,39,40 Parkinson’s disease,41 and stroke.42

Suppressing Inflammatory Cytokines

Caloric restriction inhibits expression of genes that produce inflammatory cytokines—such as interleukins and tumor necrosis factor (TNF), as well as cyclooxygenase-2 (COX-2)—that are powerfully implicated in the onset of cancer, atherosclerosis, and chronic inflammation.43-46

Resveratrol and pterostilbene block the release of a host of inflammatory cytokines and enzymes found throughout the body—particularly tissues and organs stressed by environmental factors, infection, or trauma.22,47,48 Pterostilbene powerfully suppresses the expression of inflammatory COX-2,31,49 helping lower the risk of cancer as well as a host of inflammatory diseases.50,51

Quercetin inhibits the COX-2 enzyme involved in early-stage colon cancer, and suppresses numerous cytokines involved in allergies and autoimmune disorders.34,35,53

Grape seed extract specifically prevents fatty tissue from releasing inflammatory cytokines and adipokines that would otherwise provoke insulin resistance and atherosclerosis associated with metabolic syndrome.37 By downregulating reactive cytokines, grape seed extract has been shown in animals to protect organs from ischemia-reperfusion damage (injury caused by the return of blood flow after a period of restriction).54

Black tea extract reduces levels of STAT-1, a protein which “tells” the cell nucleus to activate genes that produce inflammatory cytokines.55

Cancer Prevention

Calorie restriction (CR) upregulates genes that suppress cancer and downregulates genes that permit cancers to form or spread. CR prevents cancer cell reproduction and proliferation, while inhibiting the blood vessel growth cancer cells require to develop and metastasize.46,56-62

Resveratrol and pterostilbene mirror these effects. They combat cancer at every stage of development, inducing apoptosis (programmed cell death) in a variety of human cancer types, while preserving healthy cells.32,63-66 Resveratrol also suppresses cancer proliferation by modulating expression of proteins involved in the reproductive cycle of abnormal cells.67,68

Quercetin activates “executioner” proteins while inhibiting survival proteins in human cancer cells, blocking their reproduction.69-71 Quercetin and resveratrol have also been shown to block the expression of vascular endothelial growth factor (VEGF), an effect that may help starve tumors of their blood supply.72

Grape seed extract induces expression of a protein that arrests cancer cells early in their reproductive cycle, preventing further development and destroying them.73 Similar to quercetin, grape seed extract fights angiogenesis by suppressing the VEGF signaling pathway.74

Black tea extract reduces expression of genes that cancer cells use to proliferate, survive, infiltrate healthy tissue, supply themselves with blood, and metastasize to other organs.75 It has also been shown to upregulate expression of proteins that arrest the cell reproductive cycle and induce cellular death specifically in cancers.76

Enhanced Glucose Control

Caloric restriction enhances glucose control.77,78 Recall that not one of the Rhesus monkeys in the study discussed earlier developed diabetes or exhibited symptoms of impaired glucose control.9 Caloric restriction triggers gene regulators called peroxisome proliferator-activated receptors (PPARs), a class of proteins responsible for healthy fat and carbohydrate metabolism. They also play key roles in optimizing mitochondrial health57,59 and thwarting the onset of metabolic syndrome and diabetes.79


Life Extension - Health And Medical Findings

Resveratrol80 and pterostilbene81,82 upregulate the production and activity of PPAR, launching a set of cellular processes that support a youthful metabolic profile. The PPAR activator resveratrol has been shown to:

  • Prevent fat cells from absorbing sugar and converting it to fat83
  • Reduce inflammation and insulin resistance in fat cells84
  • Boost mitochondrial function 85

Grape seed extract modulates a different set of PPARs that regulate fat storage. Grape seed extract induces fat metabolism while inhibiting the development of new fat cells.86.87 It also protects endothelial cells by preventing the inflammatory response to proteins damaged by glucose (the age-accelerating process known as glycation).88

Resveratrol further exerts a favorable influence on blood sugar metabolism at the cellular level, reducing glucose production in liver cells in a way that mimics prolonged calorie restriction.89 In diabetic animals, resveratrol has been shown to help restore blood sugar to normal by modulating the activity of several enzymes involved in sugar metabolism.90

Pterostilbene and grape seed extract generate similar beneficial changes that help promote healthy blood sugar levels.91,92 Grape seed extract activates genes that trigger glucose uptake. This assists cells in the absorption and removal of glucose from circulation.92

Quercetin has been shown to stimulate the proliferation of pancreatic cells that help modulate blood glucose levels in both diabetic and non-diabetic animal models.93 It also markedly reduces expression of the enzyme that produces sorbitol, a sugar alcohol known to cause cataracts and blindess.94


Black tea extract polyphenols inhibit lipase,95 an enzyme that breaks down fat in the stomach and small intestines. This helps block absorption of fat into the bloodstream.96

In animal models, the theaflavins in black tea extract prevent after-meal elevations in blood glucose and may protect against the metabolic syndrome.97,98 This effect may help increase signaling for a powerful longevity factor called FOXO1a.99

Summary

Caloric restriction (CR) is the most scientifically validated method shown to reliably extend life span in multiple species, from microorganisms to mammals.

A milestone 20-year study provides the most conclusive evidence to date of its efficacy in Rhesus monkeys, our close genetic relatives. The discovery of calorie restriction-mimicking nutrients makes it possible for aging humans to emulate some of CR’s beneficial mechanisms of action, especially as an adjunct to modestly reducing one’s overall calorie intake.100 The unique ability of these nutrients to modulate gene expression exerts system-wide effects that, in addition to influencing many of the same pathways activated by calorie restriction, can also significantly reduce degenerative disease risk.

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